Posted by LINAO HUANG
on January 28, 2026
As a physician trained in functional and nutritional medicine, one of the recurring challenges I see with dietary supplements is not what is inside the capsule, but how it is delivered. The way an active compound is absorbed, metabolized, and sustained in the body often determines whether a supplement provides measurable benefits—or simply passes through unused.
This is precisely why we adopted Triphasic Release Technology (TRT) for our berberine formulation. Let’s take a closer look at the science.
The Problem with Conventional Delivery
Most traditional supplements release their active ingredient all at once. While this may look effective on paper, in reality it creates two challenges:
1.Rapid spikes and quick clearance –The body absorbs a large amount within a short time, often leading to fluctuating blood concentrations. With compounds like berberine, this means benefits may be short-lived.
2.Digestive tolerance issues –Sudden exposure to higher concentrations can sometimes increase the risk of gastrointestinal discomfort.
Scientific literature has shown that steady plasma concentrations are often more effective than erratic peaks, especially for metabolic support compounds .
The Logic of Triphasic Release
Triphasic Release Technology is designed to mimic the body’s natural rhythms by delivering active ingredients in three carefully engineered phases:
Immediate Release Phase
Provides an initial, effective concentration to quickly engage metabolic pathways.
Sustained Release Phase
Maintains stable blood levels, avoiding the rapid drop-off that comes with standard capsules.
Extended Release Phase
Prolongs activity for several hours, supporting around-the-clock benefits without repeated dosing.
This multi-stage release pattern is not accidental—it is based on pharmacokinetic modeling and absorption studies that show consistent delivery improves both efficacy and tolerability .
Backed by Evidence
Clinical research on berberine has consistently pointed to the importance of steady plasma concentrations. For example:
A randomized controlled trial demonstrated that divided or sustained dosing improved metabolic outcomes compared with single high doses.
Pharmacological studies (Li et al., 2019; Turner et al., 2020) indicate that controlled-release formulations may reduce gastrointestinal side effects while extending activity.
Triphasic Release aligns with this evidence—providing the body with a more natural, efficient, and tolerable way to absorb berberine.
Why It Matters for Long-Term Use
For individuals seeking daily metabolic support, consistency is everything. A delivery system that prevents sharp peaks and troughs not only enhances clinical efficacy but also makes supplementation more comfortable for long-term adherence. Importantly, this technology is designed for sustained wellness support, not dependency.
Key Takeaway
The decision to use Triphasic Release Technology is not about novelty—it is about science-based delivery. By optimizing absorption and maintaining steady effectiveness, this system ensures that every capsule works in alignment with your body’s physiology.
In functional medicine, precision matters. And when it comes to berberine, how you deliver it can be just as important as the ingredient itself.
